D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d<sub>7</sub>

By Targets:	SphK (10) Antibiotic (1) Apoptosis (11) Aryl Hydrocarbon Receptor (1) Autophagy (4) Bacterial (1) Biochemical Assay Reagents (1) Ceramidase (2) Cytochrome P450 (1) Drug Metabolite (2) Endogenous Metabolite (12) Estrogen Receptor/ERR (2) FAAH (1) Fluorescent Dye (1) Isotope-Labeled Compounds (15) Leukotriene Receptor (2) Liposome (1) LPL Receptor (25) Nucleoside Antimetabolite/Analog (7) p38 MAPK (1) PAK (3) Phosphatase (1) Phospholipase (3) PKC (7) Small Interfering RNA (siRNA) (1) Topoisomerase (2) TRP Channel (1)
By Research Areas:	Cancer (38) Cardiovascular Disease (4) Endocrinology (2) Infection (4) Inflammation/Immunology (26) Metabolic Disease (7) Neurological Disease (9)
Click Chemistry:	Alkynes (1)

Targets Recommended: SphK P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-146923S

*D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7*	Isotope-Labeled Compounds	Others
D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.

HY-146922S

*D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7*	Isotope-Labeled Compounds	Others
D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.

HY-146764S

*D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine-d7*	Isotope-Labeled Compounds	Others
D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine.

HY-N10636

D-lactosyl-β-1,1′ N-stearoyl-D-erythro-sphingosine

Others Others

D-lactosyl-β-1,1′ N-stearoyl-D-erythro-sphingosine is a neutral glycolipid .

D-lactosyl-β-1,1′ N-stearoyl-D-erythro-sphingosine	Others	Others
D-lactosyl-β-1,1′ N-stearoyl-D-erythro-sphingosine is a neutral glycolipid .

HY-146921S

*3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine-d7 ammonium*	Isotope-Labeled Compounds	Others
3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine-d₇ (ammonium) is deuterium labeled 3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine (ammonium).

HY-131701S

Lactosyl-C18-sphingosine-d7

Isotope-Labeled Compounds Others

Lactosyl-C18-sphingosine-d₇ is deuterium labeled Lactosyl-C18-sphingosine.

Lactosyl-C18-sphingosine-d7	Isotope-Labeled Compounds	Others
Lactosyl-C18-sphingosine-d₇ is deuterium labeled Lactosyl-C18-sphingosine.

HY-141630

Sphingosine-1-phosphate (d17:1) D-erythro-sphingosine-C17-1-phosphate	Others	Cancer
Sphingosine-1-phosphate d17:1 (D-erythro-Sphingosine-C17-1-phosphate) is a derivative of ceramide. Sphingosine-1-phosphate d17:1 can be used for the research of cancer .

HY-101047S

*D-erythro-Sphingosine-d7* erythrosphingosine-d<sub>7sub>; erythro-C18-sphingosine-d<sub>7sub>; trans-4-Sphingenine-d<sub>7sub>	PKC Phosphatase Endogenous Metabolite	Cancer
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

HY-W089922

*D-erythro-Sphingosine* hydrochloride** 2 Publications Verification erythrosphingosine hydrochloride; erythro-C18-sphingosine hydrochloride; trans-4-Sphingenine hydrochloride	TRP Channel	Neurological Disease
D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation .

HY-101047

D-erythro-Sphingosine 2 Publications Verification erythrosphingosine; erythro-C18-sphingosine; trans-4-Sphingenine
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-146908S

N-Pentadecanoyl-D-erythro-sphingosine-d7

Isotope-Labeled Compounds Others

N-Pentadecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled N-Pentadecanoyl-D-erythro-sphingosine.

*N-Pentadecanoyl-D-erythro-sphingosine-d7*	Isotope-Labeled Compounds	Others
N-Pentadecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled N-Pentadecanoyl-D-erythro-sphingosine.

HY-146766S

*D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine-d7*	Isotope-Labeled Compounds	Others
D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine.

HY-146761S

*3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d7*	Isotope-Labeled Compounds	Others
3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled 3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine.

HY-116392G

*D,L-erythro-PDMP*	Others	Others
D,L-erythro-PDMP is an erythro isomer of PDMP. D,L-erythro-PDMP causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase .

HY-116392H

*D,L-erythro-PDMP hydrochloride*	Others	Others
D,L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D,L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase .

HY-134104

C20-Sphingosine

D-erythro-sphingosine-C20
Others Neurological Disease

C20-Sphingosine is a long-chain base (LCB) that can be used in the study of neural development .

C20-Sphingosine D-erythro-sphingosine-C20	Others	Neurological Disease
C20-Sphingosine is a long-chain base (LCB) that can be used in the study of neural development .

HY-130433

NBD Sphingosine	Fluorescent Dye	Others
NBD Sphingosine (NBD-Sph), a fluorochrome, is a fluorescence-labeled sphingosine. NBD Sphingosine can be uesd for fluorescence assay for sphingosine kinases .

HY-100353

C12-Ceramide N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine	Others	Metabolic Disease Cancer
C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease .

HY-108391

C8-Ceramide N-Octanoyl-D-erythro-sphingosine	Apoptosis PKC Autophagy	Inflammation/Immunology Cancer
C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro .

HY-145475

Nervonoyl ethanolamide NEA	Others	Neurological Disease Inflammation/Immunology
Nervonoyl ethanolamide (NEA) is an endogenous cannabinoid that can act as a presynaptic and postsynaptic neuromodulator. Nervonoyl ethanolamide can also be used in the research of inflammation .

HY-146996S

β-lactosyl-13C

Isotope-Labeled Compounds Others

β-lactosyl- ¹³C is the ¹³C labeled β-lactosy[1].

*β-lactosyl-13C*	Isotope-Labeled Compounds	Others
β-lactosyl- ¹³C is the ¹³C labeled β-lactosy[1].

HY-W019838S

*D-Erythro-dihydrosphingosine-d7* Sphinganine (d18:0)-d<sub>7sub>	Isotope-Labeled Compounds Endogenous Metabolite Phospholipase	Cancer
D-Erythro-dihydrosphingosine-d₇ is the deuterium labeled D-Erythro-dihydrosphingosine. D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

HY-108496S

Sphingosine-1-phosphate-d7 S1P-d<sub>7sub>	Endogenous Metabolite LPL Receptor	Endocrinology
Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

HY-W751418

*N-Nervonoyl* taurine** (Z)-2-tetracos-15-enamidoethanesulfonic acid	FAAH	Neurological Disease
N-Nervonoyl taurine ((Z)-2-tetracos-15-enamidoethanesulfonic acid) is a fatty acid-taurine conjugate derived from nervonic acid. N-Nervonoyl taurine is a substrate of fatty acid amide hydrolase (FAAH) discovered during metabolite profiling .

HY-139097

C12-Sphingosine	Others	Others
C12-Sphingosine is a short-chain Sphingosine homologue. C12-Sphingosine inhibits serine palmitoyltransferase activity in primary cultured cerebellar cells .

HY-N11536

erythro-Austrobailignan-6	Topoisomerase Apoptosis	Cancer
erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK .

HY-117152

L-threo-Sphingosine L-threo-sphingosine C-18	p38 MAPK Apoptosis	Cancer
L-threo-Sphingosine is a potent MAPK inhibitor. L-threo-Sphingosine induces apoptosis and clear DNA fragmentation. L-threo-Sphingosine shows anticancer effect .

HY-141579

Sphingosine (d17:1)	Others	Others
Sphingosine (d17:1) is a 17-carbon sphingosine found in human skin. Sphingosine (d17:1) can be phosphorylated by sphingosine kinases to produce C-17 sphingosine-1-phosphate. Sphingosine C-17 was used as an internal standard for spectral analysis of sphingoid compounds .

HY-148292

*C16-Sphingosine-1-phosphate*	LPL Receptor	Cardiovascular Disease Inflammation/Immunology
C16-Sphingosine-1-phosphate is a derivative of Sphingosine-1-phosphate and also an endogenous ligand for the EDG/S1P receptor. C16-Sphingosine-1-phosphate can be used in the research of angiogenesis, inflammation, and cardiovascular diseases .

HY-W019781

Biotinylated sphingosine Biotinyl-Sph	SphK	Metabolic Disease
Biotinylated sphingosine (Biotinyl-Sph) is a substrate of sphingosine kinase that can b used to detect the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 .

HY-146763S

N-Tridecanoyl-D-erythro-sphinganine-d7

Isotope-Labeled Compounds Others

N-Tridecanoyl-D-erythro-sphinganine-d₇ is deuterium labeled N-Tridecanoyl-D-erythro-sphinganine.
HY-N1722

(–)-Erythro-saccharinic acid lactone

(–)-Erythro-saccharinic acid lactone (compound2) can be isolated from the leaves of Talauma arcabucoana .
HY-101195

DL-erythro-Dihydrosphingosine

PKC Phospholipase Cancer

DL-erythro-Dihydrosphingosine is a potent inhibitor of PKC and phospholipase A2 (PLA2) .

*N-Tridecanoyl-D-erythro-sphinganine-d7*	Isotope-Labeled Compounds	Others
N-Tridecanoyl-D-erythro-sphinganine-d₇ is deuterium labeled N-Tridecanoyl-D-erythro-sphinganine.

*(–)-Erythro-saccharinic acid lactone*
(–)-Erythro-saccharinic acid lactone (compound2) can be isolated from the leaves of Talauma arcabucoana .

*DL-erythro-Dihydrosphingosine*	PKC Phospholipase	Cancer
DL-erythro-Dihydrosphingosine is a potent inhibitor of PKC and phospholipase A2 (PLA2) .

HY-108496

Sphingosine-1-phosphate 5 Publications Verification S1P	Endogenous Metabolite LPL Receptor	Endocrinology
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors . Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids .

HY-N3864

erythro-Guaiacylglycerol β-coniferyl ether	Others	Others
Erythro-Guaiacylglycerol beta-coniferyl ether (compound 22) can be isolated from the stems and leaves of mung beans. Erythro-Guaiacylglycerol beta-coniferyl ether inhibits α-Glycosidase activity with EC₅₀ value of 18.71 μM .

HY-N11516

Erythro-guaiacylglycerol-β-ferulic acid ether

Others Others

Erythro-guaiacylglycerol-β-ferulic acid ether is a natural product that can be isolated from Gueldenstaedtia verna .

Erythro-guaiacylglycerol-β-ferulic acid ether	Others	Others
Erythro-guaiacylglycerol-β-ferulic acid ether is a natural product that can be isolated from Gueldenstaedtia verna .

HY-N9166

erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether	Others	Others
erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether (Compound 122) inhibits lettuce germination. erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether can be isolated from Brassica fruticulosa .

HY-N7076

Aleuritic acid (±)-erythro-Aleuritic acid; α-Aleuritic acid	Others	Others
Aleuritic acid ((±)-erythro-Aleuritic acid) is a major ingredient in Croton crassifolius Geisel. and used in the perfumery industry .

HY-137422

D-erythro-MAPP

1 Publications Verification

D-e-MAPP
Ceramidase Neurological Disease Cancer

D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC₅₀ of 1-5 μM in vitro .

*D-erythro-MAPP* 1 Publications Verification D-e-MAPP	Ceramidase	Neurological Disease Cancer
D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC₅₀ of 1-5 μM in vitro .

HY-W019838

*D-Erythro-dihydrosphingosine* Sphinganine (d18:0)	Endogenous Metabolite Phospholipase	Cancer
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A₂α (cPLA₂α) activity.

HY-113116

Sphinganine 1-phosphate D-erythro-Dihydrosphingosine 1-phosphate	Endogenous Metabolite	Inflammation/Immunology Cancer
Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes .

HY-W040055S

Neopterin-13C5 D-(+)-Neopterin-¹³C<sub>5sub>; D-erythro-Neopterin-¹³C<sub>5sub>	Isotope-Labeled Compounds	Others
Neopterin- ¹³C₅ (D-(+)-Neopterin- ¹³C₅; D-erythro-Neopterin- ¹³C₅)is the deuterium labeledNeopterin(HY-W040055) . Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation .

HY-118442

Sphingosine (d14:1) Tetradecasphing-4-enine	PKC	Cancer
Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .

HY-N3859

Erythro-1-phenylpropane-1,2-diol

(1R,2S)-1-Phenyl-1,2-propanediol
Others Others

Erythro-1-phenylpropane-1,2-diol? ((1R,2S)-1-Phenyl-1,2-propanediol) is a secondary alcohol .

Erythro-1-phenylpropane-1,2-diol (1R,2S)-1-Phenyl-1,2-propanediol	Others	Others
Erythro-1-phenylpropane-1,2-diol? ((1R,2S)-1-Phenyl-1,2-propanediol) is a secondary alcohol .

HY-150513

SLP9101555	SphK	Cancer
SLP9101555 (compound 14c) is a potent and selective SphK2 (sphingosine kinase 2) inhibitor (K_i=90 nM) with 200-fold selectivity over SphK1. SLP9101555 markedly decreases extracellular S1P (sphingosine 1-phosphate) levels .

HY-W127354

*N-Tetracosanoyl-D-sphingosine* 1-benzoate**	Biochemical Assay Reagents	Others
N-Tetracosanoyl-D-sphingosine 1-benzoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-15425

PF-543 5+ Cited Publications sphingosine Kinase 1 Inhibitor II	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy .

HY-15425B

PF-543 hydrochloride sphingosine Kinase 1 Inhibitor II hydrochloride	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy .

HY-N10238

Mycestericin G

Endogenous Metabolite Inflammation/Immunology

Mycestericin G is a sphingosine-like fungal metabolite that exhibits immunosuppressive activity .

HY-146920S

*3-O-Sulfo-galactosyl(β)sphingosine* (d18:1)-d7 ammonium**	Isotope-Labeled Compounds	Others
3-O-Sulfo-galactosyl(β)sphingosine (d18:1)-d₇ (ammonium) is deuterium labeled 3-O-Sulfo-galactosyl(β)sphingosine (d18:1) (ammonium).

Cat. No.	Product Name	Type

HY-130433

NBD Sphingosine

Dyes

NBD Sphingosine (NBD-Sph), a fluorochrome, is a fluorescence-labeled sphingosine. NBD Sphingosine can be uesd for fluorescence assay for sphingosine kinases .

HY-D2284

SGPL1 fluorogenic substrate sphingosine-1-phosphate lyase fluorogenic substrate	Fluorescent Dyes/Probes
SGPL1 fluorogenic substrate is the fluorogenic substrate of sphingosine-1-phosphate lyase (SGPL1) that can be used to measure the activity of SGPL1 .

Cat. No.	Product Name	Type

HY-134427

Palmitoyl coenzyme A lithium Palmitoyl CoA lithium	Biochemical Assay Reagents
Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis .

HY-154831

C22-Ceramide N-Behenoyl-D-erythro-sphingosine; Cer d18:1/22:0	Drug Delivery
C22-Ceramide (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes .

HY-W127354

*N-Tetracosanoyl-D-sphingosine* 1-benzoate**	Biochemical Assay Reagents
N-Tetracosanoyl-D-sphingosine 1-benzoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-154922

Palmitoyl coenzyme A Palmitoyl CoA	Biochemical Assay Reagents
Palmitoyl coenzyme A is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A can also be used as a substrate for sphingosine biosynthesis .

Cat. No.	Product Name	Target	Research Area

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Peptides	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent **Plasmodium subtilisin-like protease 1 (SUB1)** inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W089922

*D-erythro-Sphingosine* hydrochloride** 2 Publications Verification erythrosphingosine hydrochloride; erythro-C18-sphingosine hydrochloride; trans-4-Sphingenine hydrochloride	Animals Source classification	TRP Channel
D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation .

HY-141579

Sphingosine (d17:1)	Animals Source classification	Others
Sphingosine (d17:1) is a 17-carbon sphingosine found in human skin. Sphingosine (d17:1) can be phosphorylated by sphingosine kinases to produce C-17 sphingosine-1-phosphate. Sphingosine C-17 was used as an internal standard for spectral analysis of sphingoid compounds .

HY-134104

C20-Sphingosine D-erythro-sphingosine-C20	Structural Classification Natural Products Source classification Endogenous metabolite	Others
C20-Sphingosine is a long-chain base (LCB) that can be used in the study of neural development .

HY-W751418

*N-Nervonoyl* taurine** (Z)-2-tetracos-15-enamidoethanesulfonic acid	Structural Classification Natural Products Source classification Endogenous metabolite	FAAH
N-Nervonoyl taurine ((Z)-2-tetracos-15-enamidoethanesulfonic acid) is a fatty acid-taurine conjugate derived from nervonic acid. N-Nervonoyl taurine is a substrate of fatty acid amide hydrolase (FAAH) discovered during metabolite profiling .

HY-N11536

erythro-Austrobailignan-6	Structural Classification Saururaceae Saururus chinensis (Lour.) Baill. Source classification Lignans Phenylpropanoids Plants	Topoisomerase Apoptosis
erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK .

HY-108496

Sphingosine-1-phosphate 5 Publications Verification S1P	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite LPL Receptor
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors . Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids .

HY-N3864

erythro-Guaiacylglycerol β-coniferyl ether	Structural Classification Monophenols Source classification Celastraceae Other Phenylpropanoids Phenols Phenylpropanoids Plants Euonymus alatus (Thunb.) Sieb.	Others
Erythro-Guaiacylglycerol beta-coniferyl ether (compound 22) can be isolated from the stems and leaves of mung beans. Erythro-Guaiacylglycerol beta-coniferyl ether inhibits α-Glycosidase activity with EC₅₀ value of 18.71 μM .

HY-N11516

Erythro-guaiacylglycerol-β-ferulic acid ether	Other Terpenoids Structural Classification Leguminosae Terpenoids Source classification Plants Gueldenstaedtia verna (Georgi) Boriss.	Others
Erythro-guaiacylglycerol-β-ferulic acid ether is a natural product that can be isolated from Gueldenstaedtia verna .

HY-N9166

erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether	Structural Classification Cornaceae Source classification Lignans Phenylpropanoids Plants	Others
erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether (Compound 122) inhibits lettuce germination. erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether can be isolated from Brassica fruticulosa .

HY-N7076

Aleuritic acid (±)-erythro-Aleuritic acid; α-Aleuritic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Euphorbiaceae Croton crassifolius Geisel. Plants Disease Research Fields	Others
Aleuritic acid ((±)-erythro-Aleuritic acid) is a major ingredient in Croton crassifolius Geisel. and used in the perfumery industry .

HY-W019838

*D-Erythro-dihydrosphingosine* Sphinganine (d18:0)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Phospholipase
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A₂α (cPLA₂α) activity.

HY-113116

Sphinganine 1-phosphate D-erythro-Dihydrosphingosine 1-phosphate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite
Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes .

HY-118442

Sphingosine (d14:1) Tetradecasphing-4-enine	Natural Products Classification of Application Fields Animals Source classification Disease Research Fields Cancer	PKC
Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .

HY-N3859

Erythro-1-phenylpropane-1,2-diol (1R,2S)-1-Phenyl-1,2-propanediol	Structural Classification Natural Products Microorganisms Source classification	Others
Erythro-1-phenylpropane-1,2-diol? ((1R,2S)-1-Phenyl-1,2-propanediol) is a secondary alcohol .

HY-N10238

Mycestericin G	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Inflammation/Immunology	Endogenous Metabolite
Mycestericin G is a sphingosine-like fungal metabolite that exhibits immunosuppressive activity .

HY-154922

Palmitoyl coenzyme A Palmitoyl CoA	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Palmitoyl coenzyme A is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A can also be used as a substrate for sphingosine biosynthesis .

HY-134427

Palmitoyl coenzyme A lithium Palmitoyl CoA lithium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis .

HY-129099

N-Desmethyltamoxifen	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-129099A

N-Desmethyltamoxifen hydrochloride	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-125833

Alpha-Naphthoflavone 5 Publications Verification	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-W040055

Neopterin D-(+)-Neopterin; D-erythro-Neopterin	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	Endogenous Metabolite
Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation.

Species:	Human (13) Rat (1)
Tag:	GFP (3) His (11) SUMO (1) Tag Free (2) Strep (3) GST (1) Trx (1)
Source:	HEK293 (3) E. coli Cell-free (5) Sf9 insect cells (1) Sf9 insect cells (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P702765

SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, 363a.a)

SK1; sphingosine kinase 1; SPHK1; SPK 1; SPK
Human Sf9 insect cells

HY-P73421

	*SPHK1/Sphingosine* Kinase 1 Protein, Human (sf9)** SK1; sphingosine kinase 1; SPHK1; SPK 1; SPK	Human	Sf9 insect cells
	The SPHK1/sphingosine kinase 1 protein is a multifunctional lipid mediator that phosphorylates sphingosine to generate sphingosine-1-phosphate (SPP). SPHK1/Sphingosine Kinase 1 Protein, Human (sf9) is the recombinant human-derived SPHK1/Sphingosine Kinase 1 protein, expressed by Sf9 insect cells , with tag free. The total length of SPHK1/Sphingosine Kinase 1 Protein, Human (sf9) is 384 a.a., with molecular weight of ~46 kDa.

HY-P73631

	*SPHK1/Sphingosine* Kinase 1 Protein, Human (sf9, His-GST)** sphingosine kinase 1; SPK 1; SPHK1; SPK	Human	Sf9 insect cells
	The SPHK1/sphingosine kinase 1 protein is a multifunctional lipid mediator that phosphorylates sphingosine to generate sphingosine-1-phosphate (SPP). SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, His-GST) is the recombinant human-derived SPHK1/Sphingosine Kinase 1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, His-GST) is 384 a.a., with molecular weight of ~64 kDa.

HY-P702426

	S1PR2 Protein, Rat (Cell-Free, His) sphingosine 1-phosphate receptor 2; AGR16; Endothelial differentiation G-protein coupled receptor 5; G-protein coupled receptor H218; sphingosine 1-phosphate receptor Edg-5; S1P receptor Edg-5	Rat	E. coli Cell-free
	S1PR2 Protein, a receptor for S1P, induces diverse physiological effects in cells and tissues. It also serves as a receptor for FAM19A5, mediating FAM19A5's inhibitory impact on vascular smooth muscle cell proliferation and migration. S1PR2 Protein, Rat (Cell-Free, His) is the recombinant rat-derived S1PR2 protein, expressed by E. coli Cell-free , with C-10*His labeled tag. The total length of S1PR2 Protein, Rat (Cell-Free, His) is 352 a.a., with molecular weight of 41.6 kDa.

HY-P74650

	*PC4/SUB1 Protein, Human (His)* Activated RNA polymerase II transcriptional coactivator p15; PC4; p14; sub1; RPO2TC1	Human	E. coli
	The PC4/SUB1 protein acts as a multifunctional coactivator that cooperates with TAF to promote functional interactions between upstream activators and the general transcription machinery. Its role extends to the potential stability of multiprotein transcription complexes. PC4/SUB1 Protein, Human (His) is the recombinant human-derived PC4/SUB1 protein, expressed by E. coli , with N-His labeled tag. The total length of PC4/SUB1 Protein, Human (His) is 127 a.a., with molecular weight of ~19 kDa.

HY-P702197

	ABCD3 Protein, Human (Cell-Free, His) ATP-binding cassette sub-family D member 3; 70 kDa peroxisomal membrane protein; PMP70	Human	E. coli Cell-free
	ABCD3 is a member of the ATP-binding cassette (ABC) family. ABCD3 Protein, Human (Cell-Free, His) is the recombinant human-derived ABCD3 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of ABCD3 Protein, Human (Cell-Free, His) is 659 a.a., with molecular weight of 81.5 kDa.

HY-P7621

	ABCB5 Protein, Human (Trx) rHuABCB5, N-Trx; ATP-binding cassette sub-family B member 5; P-glycoprotein ABCB5; ABCB5	Human	E. coli
	ABCB5, N-Trx Protein, Human is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.

HY-P72012

	ABCD1 Protein, Human (Cell-Free, His) ABC42; Abcd1; ABCD1_HUMAN; Adrenoleukodystrophy protein; ALD; Aldgh; ALDP; AMN; ATP binding cassette; sub family D ALD; ; member 1; ATP-binding cassette sub-family D member 1; OTTHUMP00000025960; OTTMUSP00000019283; RGD1562128; RP23 373N8.2; X linked adrenoleukodystrophy ALD; gene homolog	Human	E. coli Cell-free
	ABCD1, Human (His) is one of the four ATP-binding cassette (ABC) proteins in subfamily D. Dysfunction of ABCD1 causes neurodegenerative disorder X-linked adrenoleukodystrophy (X-ALD).

HY-P702196

	ABCD2 Protein, Human (Cell-Free, His) ATP-binding cassette sub-family D member 2; Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR	Human	E. coli Cell-free
	ABCD2 protein is an ATP-dependent transporter in the ABC family that promotes the transport of very long chain fatty acids (VLCFA)-CoA into peroxisomes and exhibits fatty acyl-CoA thioesterase (ACOT) and ATPase activities. Its substrate specificity overlaps with ABCD1, including a clear preference for shorter VLCFA (C22:0) and polyunsaturated fatty acids (PUFA) such as C22:6-CoA and C24:6-CoA. ABCD2 Protein, Human (Cell-Free, His) is the recombinant human-derived ABCD2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of ABCD2 Protein, Human (Cell-Free, His) is 740 a.a., with molecular weight of 89.3 kDa.

HY-P702195

	ABCB8 Protein, Human (Cell-Free, His, SUMO) Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial ATP-binding cassette 1; M-ABC1; Mitochondrial sulfonylurea-receptor; MITOSUR	Human	E. coli Cell-free
	ABCB8 is the ATP-binding subunit of mitochondrial potassium channels and cooperates with CCDC51/MITOK to form mitoK (ATP) channels in the inner mitochondrial membrane. This complex promotes ATP-dependent potassium currents. ABCB8 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived ABCB8 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of ABCB8 Protein, Human (Cell-Free, His, SUMO) is 656 a.a., with molecular weight of 87 kDa.

HY-P72069

	ABCC1 Protein, Human (His) ABC 29; ABC29; ABCC 1; ABCC; Abcc1; ATP binding cassette sub family C CFTR/MRP; member 1; ATP binding cassette sub-family C member 1; ATP binding cassette subfamily C member 1; ATP binding cassette transporter variant ABCC1delta ex13; ATP binding cassette transporter variant ABCC1delta ex13&14; ATP binding cassette transporter variant ABCC1delta ex25; ATP binding cassette transporter variant ABCC1delta ex25&26; ATP binding cassette, sub-family C CFTR/MRP; , member 1; ATP-binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C4; transporter; LTC4 transporter; MRP 1; MRP; MRP1; MRP1_HUMAN; Multidrug resistance associated protein 1; Multidrug resistance protein; Multidrug resistance-associated protein 1; Multiple drug resistance associated protein; Multiple drug resistance protein 1	Human	E. coli
	ABCC1, Human (His) is a multitasking ATP-binding cassette (ABC) transporter. ABCC1, Human plays a part in inflammatory and other immunological diseases, age-related macular degeneration, cardiovascular disease, and certain neurological disorders as well as tumor progression.

HY-P701354

	ABCC4 Protein, Human (HEK293, GFP, Strep, His) ABCC4; ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B; Multidrug resistance-associated protein 4	Human	HEK293
	ABCC4 Protein, an ATP-binding cassette (ABC) family member, actively transports endogenous compounds (cAMP, cGMP, bile acids) and xenobiotics from cells. Its versatility extends to glutathione conjugates (LTC4, LTB4) and drug metabolites, mediating cotransport of bile acids with reduced glutathione. ABCC4's function includes resistance to anticancer agents like methotrexate, highlighting its role in cellular communication and drug transport. ABCC4 Protein, Human (HEK293, GFP, Strep, His) is the recombinant human-derived ABCC4 protein, expressed by HEK293 , with C-10*His, C-GFP, C-Strep labeled tag. The total length of ABCC4 Protein, Human (HEK293, GFP, Strep, His) is 1325 a.a., .

HY-P701355

	bABCC1 Protein, Human (HEK293, GFP, Strep, His) ABCC1; Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter; LTC4 transporter	Human	HEK293
	The bABCC1 protein plays a key role in cellular physiology, mediating the ATP-dependent export of a variety of substrates, including drugs and organic anions. Notably, it confers resistance to anticancer drugs, actively reducing their intracellular accumulation. bABCC1 Protein, Human (HEK293, GFP, Strep, His) is the recombinant human-derived bABCC1 protein, expressed by HEK293 , with C-10*His, C-GFP, C-Strep labeled tag. The total length of bABCC1 Protein, Human (HEK293, GFP, Strep, His) is 1530 a.a., .

HY-P701356

	bABCC1 Protein, Human (HEK293, E1454Q, GFP, Strep, His) ABCC1; Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter; LTC4 transporter	Human	HEK293
	The bABCC1 protein plays a key role in cellular physiology, mediating the ATP-dependent export of a variety of substrates, including drugs and organic anions. Notably, it confers resistance to anticancer drugs, actively reducing their intracellular accumulation. bABCC1 Protein, Human (HEK293, E1454Q, GFP, Strep, His) is the recombinant human-derived bABCC1 protein, expressed by HEK293 , with C-10*His, C-GFP, C-Strep labeled tag and E1454Q, , , , mutation. The total length of bABCC1 Protein, Human (HEK293, E1454Q, GFP, Strep, His) is 1530 a.a., .

Cat. No.	Product Name	Chemical Structure

HY-146923S

D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7

D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.

HY-146922S

*D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7*
D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.

HY-146764S

*D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine-d7*
D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine.

HY-146921S

*3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine-d7 ammonium*
3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine-d₇ (ammonium) is deuterium labeled 3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine (ammonium).

HY-131701S

Lactosyl-C18-sphingosine-d7

Lactosyl-C18-sphingosine-d₇ is deuterium labeled Lactosyl-C18-sphingosine.

HY-101047S

*D-erythro-Sphingosine-d7*
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

HY-146908S

N-Pentadecanoyl-D-erythro-sphingosine-d7

N-Pentadecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled N-Pentadecanoyl-D-erythro-sphingosine.

HY-146766S

*D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine-d7*
D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine.

HY-146761S

*3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d7*
3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled 3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine.

HY-146996S

β-lactosyl-13C

β-lactosyl- ¹³C is the ¹³C labeled β-lactosy[1].

HY-W019838S

*D-Erythro-dihydrosphingosine-d7*
D-Erythro-dihydrosphingosine-d₇ is the deuterium labeled D-Erythro-dihydrosphingosine. D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

HY-108496S

Sphingosine-1-phosphate-d7

Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

HY-146763S

N-Tridecanoyl-D-erythro-sphinganine-d7

N-Tridecanoyl-D-erythro-sphinganine-d₇ is deuterium labeled N-Tridecanoyl-D-erythro-sphinganine.

HY-W040055S

Neopterin-13C5
Neopterin- ¹³C₅ (D-(+)-Neopterin- ¹³C₅; D-erythro-Neopterin- ¹³C₅)is the deuterium labeledNeopterin(HY-W040055) . Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation .

HY-146920S

*3-O-Sulfo-galactosyl(β)sphingosine* (d18:1)-d7 ammonium**
3-O-Sulfo-galactosyl(β)sphingosine (d18:1)-d₇ (ammonium) is deuterium labeled 3-O-Sulfo-galactosyl(β)sphingosine (d18:1) (ammonium).

HY-12355S

Siponimod-d11
Siponimod-d11 is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P₁ and S1P₅ over S1P₂, S1P₃, and S1P₄, with EC₅₀s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research .

HY-11063S1

Fingolimod-d4 hydrochloride
Fingolimod-d₄ (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].

HY-11063S

Fingolimod-d4
Fingolimod-d₄ is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

Cat. No.	Product Name	Application	Reactivity

HY-P82614

EDG3 Antibody (YA2359) S1PR3; EDG3; sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P3; Endothelial differentiation G-protein coupled receptor 3; sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3	WB	Human, Mouse, Rat

HY-P80527

ABCB5 Antibody (YA836) ABCB5 P-gp; ATP binding cassette sub family B (MDR/TAP) member 5; P glycoprotein ABCB5	WB, ICC/IF	Human
ABCB5 Antibody (YA836) is a non-conjugated and Mouse origined monoclonal antibody about 139 kDa, targeting to ABCB5 (8D2). It can be used for WB,ICC/IF assays with tag free, in the background of Human.

HY-P80772

P Glycoprotein Antibody p-pg; ABCB1; MDR1; PGY1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD antigen CD243	WB	Human
P Glycoprotein Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 141 kDa, targeting to P Glycoprotein. It can be used for WB assays with tag free, in the background of Human.

HY-P81118

MRP2/ABCC2 Antibody multidrug resistance-associated protein2; ABC30; ABCC2; ATP binding cassette sub family C (CFTR/MRP) member 2; ATP binding cassette subfamily C member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; CMOAT; CMOAT1; cMRP; DJS; KIAA1010; MRP 2; MRP-2; MRP2; Multidrug resistance associated protein 2; MRP2_HUMAN; ATP-binding cassette sub-family C member 2; Multidrug resistance-associated protein 2.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse, Rat,
MRP2/ABCC2 Antibody is an unconjugated, approximately 174 kDa, rabbit-derived, anti-MRP2/ABCC2 polyclonal antibody. MRP2/ABCC2 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, background without labeling.

Cat. No.	Product Name		Classification

HY-145472

Sphingosine (d18:1) alkyne

Alkynes

Sphingosine (d18:1) alkyne (compound 2b) is an alkyne-labeled Sphingosine (d18:1) that can be used in click chemistry reactions .


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